From Ehime : Ferry, Car

Car ferry: 2 hours and 40 minutes from Matsuyama Kankoko to Kure Port and then to Hiroshima Port.
Super-jet Ferry: 1 hour and 8 minutes from Matsuyama Kankoko to Hiroshima Port.
Private automobile:
Approximately 190 km from the Matsuyama Interchange on the Matsuyama Expressway, along the Shimanami Kaido, to the Hiroshima-higashi Interchange on the Sanyo Expressway.
Then, approximately 20 minutes from Hiroshima-higashi Interchange to Hiroshima Station.